I like FLAC, but if I bog a system down enough, playback goes to hell. I like Ogg, since it supports multichannel audio.
Apple Lossless just pisses me off. It won't play in ANYTHING I use. AACs are almost as bad, simply because an AAC is a container format that might have Apple Lossless in it. APE pisses me off, since most of the time APE files are provided as a large file with a CUE instead of as single tracks, and beyond that you get into weird crap like WavePack, which pisses me off because I have to go looking for a converter or something.
dbPowerAmp can convert anything into a non-sucky format. APEs and m4as and AACs and other stupid formats can be changed to something decent with as little as a context-click.