The PostureFit adjustable lumbar feature is what makes the Aeron, IMO. It's one of the few ergo chairs that actually allow the lumbar support to be positioned low enough on the back (more like a lumbro-sacral support, really) to be anatomically useful.
Most lumbar supports just fill in the curve of your back above the waist to the middle of your back, but the chair usually curves away from you below your waist and leaves a "black hole of support" from below your waist to your tailbone, allowing your pelvis to rotate and put pressure on your discs. The Aeron PostureFit is one of the few chairs to correct that stupid design flaw most chairs are afflicted with.
The one ergo/anatomic flaw of the Aeron IMO is the design of the seat bottom. It's designed a bit like a speed bump with the crest closer to the front going laterally across the chair and tapering down towards the front and back. I feel the rise is bit too extreme, encouraging the thighs to tilt upwards a bit and have the knees higher relative to the hips and closing the hip angle (should not be less than 120 degrees). If you have a high foot rest and use it, it's will minimize the strain of having your knees so high, but not too many people use foot rests.