Tonight I got to play Cards Against Humanity with a dream team line up: Four lesbians, two transsexuals, a (culturally) Jewish Doctor of Unitarian Theology, a Medical Doctor, an English Lit prof and two seventeen year olds, who were both dating AND both of whose mothers were somewhere in the group. The racist, homophobic, drug and porn fueled wrongness had layers of far, far deeper meaning than I suspect it typically has. It was pretty damned awesome.
I didn't have quite that good of a mix of people but last summer I brought the game with me on vacation that was spent with the in-laws and it was awesome to see some of the female players who struggled with the less than pure nature of the game. They are all faithful to Catholicism coming with their own version of pureness that was corrupted by this game. It was also sad in some spots where cards like pixelated bukkake left a lot of blank stares from the holders of that card. There were a few other cards that had to be explained which certainly takes away some of the humor when they didn't know how to properly match it up to the black card.