We just want our rat hole back. It was there for actual decades before anyone did anything about it, and it was well known enough to be a joke around Chicago for at least the last five years or so.
Estradiol isn't illegal. It's a controlled substance in about the same way as a common antibiotic and nothing particularly bad will happen if you take it when it isn't prescribed to you unless you keep doing it over and over for a long time. There are plenty of reasons women need it for hormone replacement but it's also commonly available as a street drug for people who don't want to go through formal gender confirmation processes, which often involve months or years of arguing with a psychiatrist.
Something I have learned about because of my side hustle is that Chicago is the end of a pipeline that originates in the south, moves to New Orleans and then up north. Trans or Pretrans persons go to NOLA or Atlanta as places that are relatively hospitable to the queer-of-gender and then travel north to Chicago (because the city offers easy access to affirming medical care and, you know, human rights) when spots open up in the various programs that allow for low cost treatment. Official affirming care is often adversarial since many providers want to involve multiple specialists including mental health practitioners, who generally are asked to keep people from making changes to their bodies, although this is finally starting to change. Because of this, hormone treatments of all sorts are often sold outside prescription drug systems. All you really need it to make it is someone with a .edu email address and a shipping address at a university or hospital to order the basic substances involved, plus a couple thousand bucks worth of materials and some basic chemistry gear.