Lexus cars are generally well isolated - too isolated for my taste, but YMMV. Also check out the Toyota Avalon, which shares the basic platform.
It looks like the Avaton has messed up the suspension and it is too hard, but supposedly is new for 2016. Perhaps there is a good compromise?
I may have rejectejected that model once but it is on the reconsider list.
Are the Toyotas reliable cars any more? I recall a few years ago they were going berserk and killing people or something. FWD is good and so is mileage for a V6.